More than likely the cause is that Windows renamed the drive to a letter that is already in use.
This will happen if you have several card readers, thumb drives or external hard drives attached.
It will also happen if you are on a data pipe and have mapped drives.
To find the drive and then rename it, you’ll want to right-choose My Computer and select Manage.
From the Computer Management screen, select Disk Management.
In this instance I am going to change the drive letter of my Lexar USB drive.
We don’t want to, so just click Change.