Its a right-centric world, with everything from pencils to computer mice expecting you to be right-handed.
Enter mouse in your Start menu search, and snag the first entry.
Check the Switch primary and secondary buttons box to make your mouse more left-hand friendly.
MSDN has a free set of cursors designed for left-handed users, that can fix this problem for you.
The cursors are available in 3 sizes: normal, large, and extra large.
Click each link to download all 6 cursors for your size (link below).
Click I Agree after selecting the cursors to accept the license agreement and download them.
after you grab all 6 cursors downloaded, pick the Pointers tab in the Mouse Properties dialog.
hit the cursor to change, and then click Browse to snag the new cursor.
Do this for each of the 6 cursors to be changed.
All the other ones look and act like their standard counterparts.
Finally click Ok to shut the Mouse Properties dialog and accept the changes.
Now your pointers will be easier to use left-handed!
We included all of the 6 cursors for you in a zip file you candownload Here.